Metabolic Regulation During the Co-Existence of COPD and DM type2
Background: COPD (chronic obstructive pulmonary disease) prevalence among patients with diabetes mellitus (DM)/metabolic syndrome (MetS) is high.
Material and methods: 2800 patients were screened: smokers/ex-smokers with risk of DM, DM type2, MetS. Smokers/ex-smokers with DM/MetS-22%, smokers/ex-smokers with COPD without DM/MetS-12%, smokers/ex-smokers without COPD and DM-66%. Fasting blood glucose, Glycated hemoglobin (HbA1c), Homeostasis Model Assessment (HOMA), spirometry was done.
Results: COPD was initially detected in 18% of screened patients with DM/Mets. In this patients hyperglycemia were significantly associated with FEV1 rather than only in COPD (Glucose<6 mmol/l,FEV1-75%;Glucose 6-6.9mmol/l,FEV1-71%;Glucose 7-8.9 mmol/l,FEV1-68%;Glucose>9 mmol/l,FEV1-55%,P<0.005).
Conclusion: COPD spreading is high in patients with glucose metabolism disturbance. It negatively affects FEV1. Complications frequency (25% vs 11%) is significantly higher (P<0.005) in COPD and DM/MetS coexistence, rather than only in COPD. Spirometry screening is necessary in patients with glucose metabolism disturbance for early detection of COPD.
References: Aibek E Mirrakhimov Cardiovascular Diabetology 2012; 11:132
Kasirye Y, et al. WMJ.2013; 112(6):244-9.
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