High-sensitive cardiac troponin after CPAP in obstructive sleep apnoea
Mary Sau-Man Ip, Hung-Fat Tse, David Chi-Leung Lam, Macy Mei-Sze Lui
European Respiratory Journal 2022 59: 2103176; DOI: 10.1183/13993003.03176-2021
We appreciate the correspondence from D. Monneret regarding the issue of analytical precision for troponin assays in the low range of concentrations, and thus the limitations in the interpretation of small decrements in troponin levels. In our study, serum biomarkers were secondary endpoints , and the findings and clinical significance of the lowering of troponin levels in the low range of concentrations certainly warrant further delineation in studies specifically targeting the possibility of subclinical myocardial injury in a group of high cardiovascular risk patients, and correlating any biochemical change with functional tests such as cardiac imaging. Regarding potential lot-to-lot variation of the troponin assay, the study samples were tested in batch assay, and paired pre- and post-CPAP samples were analysed in the same lot.
Changes in troponin levels in the low concentration range after treatment of obstructive sleep apnoea warrant further studies and functional correlation https://bit.ly/3HN9iss
- Received December 17, 2021.
- Accepted December 21, 2021.
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