Impact of bacterial coinfection on clinical outcomes in pneumococcal pneumonia
Background: Cardiovascular disorders represent the most frequent comorbidities as well as an increased risk of mortality in chronic obstructive pulmonary disease (COPD).
Objective. The main goal is to analyze the cardiovascular profile of COPD patients.
Methods: The study is performed using our 750-consecutive patient COPD database, built at Timisoara â€œVictor Babesâ€ Hospital (Oct 2014 â€“ Dec 2016). Spirometry, anthropometric parameters (e.g. gender, age, BMI, smoking status), comorbidities, and questionnaire results are recorded. We select all 570 COPD patients that are also diagnosed with at least one cardiovascular comorbidity (CVC). We consider 3 from the most frequent CVCs among our COPD patients: high blood pressure (HBP), ischemic heart disease (IHD), and congestive heart failure (CHF).
Results: The distribution of the 570 COPD-CVC patients on COPD stages is 14.7% in stage 1, 51.4% in stage 2, 27.9% in stage 3, 6% in stage 4. The incidence of CVC in our COPD database is HBP 92.3%, IHD 37.7%, and CHF 20%; these percentages clearly indicates that CVCs overlap. Fig. 1 shows that from COPD stage 1 to stage 4, the percentage of patients with 3 CVCs grows 2.5 times, while the percentage of patients with just one CVC decreases 1.6 times.
Conclusions: The results of this study highlight the fact that decreasing of respiratory function in COPD is associated with an increased number of associated highly-risk cardiovascular comorbidities.