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Changes in height and BMI in children and adolescents with primary ciliary dyskinesia (PCD) during the growth period: An iPCD cohort study


Abstract

Background: In a cross-sectional collaborative analysis within the EU project BESTCILIA, we had found significantly lower height and slightly lower BMI in PCD patients younger than 20 years of age compared to national reference data. We now assessed changes in height and BMI over time during the growth period.

Methods: We used longitudinal measurements of height and BMI from PCD patients of the iPCD Cohort from 10 countries. We calculated height and BMI z-scores using national references and used generalized estimating equations (GEE) to identify changes over time, as a function of sex.

Results: We analysed 1833 repeated measurements of height and BMI from 343 patients aged 0-20 years. We found a significantly lower height (z-score: -0.16, 95%CI: -0.30 to -0.02, p=0.03) and BMI (-0.15, -0.31 to -0.03, p=0.05) in PCD patients compared to reference. We found no significant change in height z-scores (p=0.93) but a small increase in BMI z-scores (0.02 per year, 0.01 to 0.03, p<0.001) over time compared to normal values. Height (p=0.30) and BMI (p=0.13) z-scores did not differ by sex.

Conclusions: Height z-scores were significantly reduced in children with PCD compared to reference values, but they did not change over time. This might suggest that PCD affects growth already at an early stage of life but there is no catch-up until the age of 20. In the ongoing study, we will look at birth weights, stratify by levels of diagnostic certainty and determine patient characteristics associated with growth, such as lung function, microbiology and clinical characteristics.

sumber : https://erj.ersjournals.com/content/48/suppl_60/pa3127.abstract?utm_source=TrendMD&utm_medium=cpc&utm_campaign=European_Respiratory_Journal_TrendMD_0

 
 

PRAKTEK Alamat 1:
RS Panti Waluya /RKZ Sawahan, Lt II-N
, Dr Koentjahja, SpP
Nusakambangan 56, Malang 65117
08113777488 / 362017 ext. 88.23
Pukul 17.45 - 19.45, hingga tgl 08 Januari 2020

Alamat 2:
RS Lavalette
, Dr Koentjahja, SpP
WR Supratman 10, Malang 65111
08133175788
Selasa & Kamis, Pukul 17.00 - 17.45, hingga tgl 08 Januari 2020

    
RUMAHWilis Indah A-6, Malang 65115
0341-568711


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