Quantitative multivolume proton-MRI in patients with cystic fibrosis lung disease: comparison with clinical indicators
ObjectivesÂ The present cross-sectional study aims to verify the relationship between quantitative multivolume magnetic resonance imaging (MRI) and clinical indicators of ventilatory abnormalities in cystic fibrosis (CF) lung disease.
MethodsÂ 28 patients (10â€“27â€…years) with CF lung disease performed non-enhanced chest MRI, spirometry and multiple breath washout (MBW). Images acquired at end-inspiration and end-expiration were registered by optical flow to estimate expiratory-inspiratory proton density change (Î”1H-MRI) as a measure of regional ventilation. MR images were also evaluated using a CF-specific scoring system.
ResultsÂ Biomarkers of CF ventilation impairment were defined from Î”1H-MRI: Î”1H-MRI median, Î”1H-MRI quartile coefficient of variation (QCV) and percent low-ventilation volume (%LVV). Imaging biomarkers correlate to all the clinical measures of ventilation abnormalities, with the strongest correlation between Î”1H-MRI median and forced expiratory volume in one second (FEV1) (r2=0.44, p<0.001), Î”1H-MRI QCV and lung clearance index (LCI) (r2=0.51, p<0.001) and %LVV and LCI (r2=0.66, p<0.001). Correlations were also found between imaging biomarkers of ventilation and morphological scoring.
ConclusionÂ The study showed a significant correlation between quantitative multivolume-MRI and clinical indicators of CF lung disease. MRI, as a non-ionizing imaging technique, may be particularly attractive in CF care for longitudinal evaluation, providing a new imaging biomarker to detect early ventilator abnormalities.
This manuscript has recently been accepted for publication in theÂ European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of theÂ ERJÂ online. Please open or download the PDF to view this article.
Conflict of interest: Dr. Pennati has nothing to disclose.
Conflict of interest: Dr. Salito has nothing to disclose.
Conflict of interest: Dr. Borzani has nothing to disclose.
Conflict of interest: Dr. Cervellin has nothing to disclose.
Conflict of interest: Dr. GAMBAZZA reports fees for consulting on Lung Clearance Index from Vertex Pharmaceuticals.
Conflict of interest: Dr. Guarise has nothing to disclose.
Conflict of interest: Dr. russo has nothing to disclose.
Conflict of interest: Dr. Colombo has nothing to disclose.
Conflict of interest: Dr. Aliverti has nothing to disclose.
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