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Quantitative multivolume proton-MRI in patients with cystic fibrosis lung disease: comparison with clinical indicators


Objectives The present cross-sectional study aims to verify the relationship between quantitative multivolume magnetic resonance imaging (MRI) and clinical indicators of ventilatory abnormalities in cystic fibrosis (CF) lung disease.

Methods 28 patients (10–27 years) with CF lung disease performed non-enhanced chest MRI, spirometry and multiple breath washout (MBW). Images acquired at end-inspiration and end-expiration were registered by optical flow to estimate expiratory-inspiratory proton density change (Δ1H-MRI) as a measure of regional ventilation. MR images were also evaluated using a CF-specific scoring system.

Results Biomarkers of CF ventilation impairment were defined from Δ1H-MRI: Δ1H-MRI median, Δ1H-MRI quartile coefficient of variation (QCV) and percent low-ventilation volume (%LVV). Imaging biomarkers correlate to all the clinical measures of ventilation abnormalities, with the strongest correlation between Δ1H-MRI median and forced expiratory volume in one second (FEV1) (r2=0.44, p<0.001), Δ1H-MRI QCV and lung clearance index (LCI) (r2=0.51, p<0.001) and %LVV and LCI (r2=0.66, p<0.001). Correlations were also found between imaging biomarkers of ventilation and morphological scoring.

Conclusion The study showed a significant correlation between quantitative multivolume-MRI and clinical indicators of CF lung disease. MRI, as a non-ionizing imaging technique, may be particularly attractive in CF care for longitudinal evaluation, providing a new imaging biomarker to detect early ventilator abnormalities.


This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.

Conflict of interest: Dr. Pennati has nothing to disclose.

Conflict of interest: Dr. Salito has nothing to disclose.

Conflict of interest: Dr. Borzani has nothing to disclose.

Conflict of interest: Dr. Cervellin has nothing to disclose.

Conflict of interest: Dr. GAMBAZZA reports fees for consulting on Lung Clearance Index from Vertex Pharmaceuticals.

Conflict of interest: Dr. Guarise has nothing to disclose.

Conflict of interest: Dr. russo has nothing to disclose.

Conflict of interest: Dr. Colombo has nothing to disclose.

Conflict of interest: Dr. Aliverti has nothing to disclose.

This is a PDF-only article. Please click on the PDF link above to read it.

sumber : https://erj.ersjournals.com/content/early/2019/02/06/13993003.02020-2017?utm_source=TrendMD&utm_medium=cpc&utm_campaign=European_Respiratory_Journal_TrendMD_0


PRAKTEK Alamat 1:
RS Panti Waluya /RKZ Sawahan, Lt II-N
, Dr Koentjahja, SpP
Nusakambangan 56, Malang 65117
08113777488 / 362017 ext. 88.23
Pukul 17.45 - 19.45, hingga tgl 08 Januari 2020

Alamat 2:
RS Lavalette
, Dr Koentjahja, SpP
WR Supratman 10, Malang 65111
Selasa & Kamis, Pukul 17.00 - 17.45, hingga tgl 08 Januari 2020

RUMAHWilis Indah A-6, Malang 65115

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