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Altered pulmonary capillary blood volume in childhood sickle cell disease


Plamen Bokov, Priscilla Boizeau, Jade Pautrat, Florence Missud, Aissatou Ba, Zinédine Haouari, André Denjean, Christophe Delclaux, Malika Benkerrou

European Respiratory Journal 2020 56: 2000379; DOI: 10.1183/13993003.00379-2020

Extract

It has consistently been shown that patients with sickle cell disease (SCD) exhibit a compensatory increase in pulmonary capillary blood volume (PCBV), at least in a specific subgroup of patients [1]. This increase in PCBV could be related to the anaemia-induced increase in cardiac output [2]. Chaudry et al. [3] showed that SCD patients failed to recruit and dilate their pulmonary capillary bed to the same extent as control subjects for a given rise in effective pulmonary blood flow. One may therefore hypothesise that PCBV is already maximally recruited at rest; however, this has yet to be confirmed. Furthermore, it is not clear whether this potential defective pulmonary vascular recruitment is related to SCD history.

Children with sickle cell disease have a pulmonary capillary blood volume that is already dilated at rest and that may initiate a restrictive defect https://bit.ly/2MRaqkc

Acknowledgements

P. Bokov and C. Delclaux thank Nicole Beydon for initiating the subject of the present study.

Footnotes

  • Conflict of interest: P. Boizeau has nothing to disclose.

  • Conflict of interest: J. Pautrat has nothing to disclose.

  • Conflict of interest: F. Missud has nothing to disclose.

  • Conflict of interest: A. Ba has nothing to disclose.

  • Conflict of interest: Z. Haouari has nothing to disclose.

  • Conflict of interest: A. Denjean has nothing to disclose.

  • Conflict of interest: C. Delclaux has nothing to disclose.

  • Conflict of interest: M. Benkerrou has nothing to disclose.

  • Conflict of interest: P. Bokov has nothing to disclose.

  • Support statement: This study was supported by the Assistance Publique – Hôpitaux de Paris. Funding information for this article has been deposited with the Crossref Funder Registry.

  • Received February 21, 2020.
  • Accepted June 5, 2020.
  • Copyright ©ERS 2020

sumber : https://erj.ersjournals.com/content/56/6/2000379

 
 

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