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Needle-based confocal laser endomicroscopy for real-time diagnosing and staging of lung cancer

Lizzy Wijmans, Joey Yared, Daniel M. de Bruin, Sybren L. Meijer, Paul Baas, Peter I. Bonta, Jouke T. Annema

European Respiratory Journal 2019 53: 1801520; DOI: 10.1183/13993003.01520-2018


Diagnosing lung cancer in the absence of endobronchial abnormalities is challenging. Needle-based confocal laser endomicroscopy (nCLE) enables real-time microscopic imaging of cells. We assessed the feasibility and safety of using nCLE for real-time identification of lung cancer.

In patients with suspected or proven lung cancer scheduled for endoscopic ultrasound (EUS), lung tumours and mediastinal lymph nodes were imaged with nCLE before fine-needle aspiration (FNA) was performed. nCLE lung cancer characteristics were identified by comparison with pathology. Multiple blinded raters validated CLE videos of lung tumours and mediastinal nodes twice.

EUS-nCLE-FNA was performed in 22 patients with suspected or proven lung cancer in whom 27 lesions (six tumours, 21 mediastinal nodes) were evaluated without complications. Three nCLE lung cancer criteria (dark enlarged pleomorphic cells, dark clumps and directional streaming) were identified. The accuracy of nCLE imaging for detecting malignancy was 90% in tumours and 89% in metastatic lymph nodes. Both inter-observer agreement (mean κ=0.68, 95% CI 0.66–0.70) and intra-observer agreement (mean±sd κ=0.70±0.15) were substantial.

Real-time lung cancer detection by endosonography-guided nCLE was feasible and safe. nCLE lung cancer characteristics were accurately recognised. nCLE might become a useful adjunct to bronchoscopy for real-time identification of lung tumours. http://ow.ly/PE7m30o8rSn


  • This article has supplementary material available from erj.ersjournals.com

  • Conflict of interest: J. Yared has nothing to disclose.

  • Conflict of interest: D.M. de Bruin has nothing to disclose.

  • Conflict of interest: S.L. Meijer has nothing to disclose.

  • Conflict of interest: P. Baas has nothing to disclose.

  • Conflict of interest: P.I. Bonta has nothing to disclose.

  • Conflict of interest: J.T. Annema reports non-financial material support from Mauna Kea Technologies during the conduct of the study.

  • Conflict of interest: L. Wijmans has nothing to disclose.

  • Support statement: The study was designed independently from commercial parties. CLE material was purchased for a reduced fee from Mauna Kea Technologies.

  • Received August 10, 2018.
  • Accepted March 18, 2019.

sumber : https://erj.ersjournals.com/content/53/6/1801520


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