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Disease severity & clinical outcomes of community acquired pneumonia


Fei Zhou, Yimin Wang, Yingmei Liu, Xuedong Liu, Li Gu, Xiaoju Zhang, Zenghui Pu, Guoru Yang, Bo Liu, Qingrong Nie, Bing Xue, Jing Feng, Qiang Guo, Jianhua Liu, Hong Fan, Jin Chen, Yongxiang Zhang, Zhenyang Xu, Min Pang, Yu Chen, Xiuhong Nie, Zhigang Cai, Jinfu Xu, Kun Peng, Xiangxin Li, Pingchao Xiang, Zuoqing Zhang, Shujuan Jiang, Xin Su, Jie Zhang, Yanming Li, Xiuhong Jin, Rongmeng Jiang, Jianping Dong, Yuanlin Song, Hong Zhou, Chen Wang, Bin Cao CAP-China network

European Respiratory Journal 2019; DOI: 10.1183/13993003.02406-2018

Disease severity and clinical outcomes of community acquired pneumonia caused by non-influenza respiratory viruses in adults: a multicenter prospective registry study from CAP-China Network

Abstract

Although a wide knowledge of influenza viral pneumonia have been established, the significance of non-influenza respiratory viruses in community acquired pneumonia (CAP) and their impact on clinical outcomes remains unclear, especially in non-immunocompromised adult population. Hospitalised immunocompetent patients with CAP were prospectively recruited from 34 hospitals in Mainland China. Respiratory viruses were detected by molecular methods. Comparisons were conducted between influenza and non-influenza viral-infection groups. In total, 915 of 2336 adult patients with viral infection were enrolled in the analysis with influenza virus (28.4%) most frequently detected, followed by respiratory syncytial virus (3.6%), adenovirus (3.3%), human coronavirus (3.0%), parainfluenza virus (2.2%), human rhinovirus (1.8%), and human metapneumovirus (1.5%). Non-influenza viral infections accounted for 27.4% of viral pneumonia. Consolidation was more frequently observed in patients with adenovirus infection. The occurrence of complications such as sepsis (40.1% versus 39.6%, p=0.890) and hypoxemia (40.1% versus 37.2%, p=0.449) during hospitalisation in influenza group didn't differ from that of non-influenza group. Compared with influenza viral infection, the multivariable-adjusted odds ratios and 95% confidence intervals (CIs) of CURB-65 >3, PaO2/FiO2 <200 mmHg, and occurrence of sepsis or hypoxemia for non-influenza viral infection were 0.87 (0.26–2.84), 0.72 (0.26–1.98), 1.00 (1.63–1.58), and 1.05 (0.66–1.65), respectively. The hazard ratio and 95% CI of 90-day mortality was 0.51 (0.13–1.91). The high incidence of complications in non-influenza viral pneumonia and similar impact of non-influenza viruses relative to influenza virus on disease severity and outcomes suggest more attention should be given to CAP caused by non-influenza viruses.

Footnotes

This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.

Conflict of interest: Fei Zhou The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Yimin Wang The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Yingmei Liu The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Xuedong Liu The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Li Gu The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission

Conflict of interest: Xiaoju Zhang The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Zenghui Pu The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Guoru Yang The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Bo Liu The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Qingrong Nie The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Bing Xue The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Jing Feng The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Qiang Guo The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Jianhua Liu The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Hong Fan The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Jin Chen The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Yongxiang Zhang The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission

Conflict of interest: Zhenyang Xu The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Min Pang The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Yu Chen The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Xiuhong Nie The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Zhigang Cai The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Jinfu Xu The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Kun Peng The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Xiangxin Li The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Pingchao Xiang The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Zuoqing Zhang The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Shujuan Jiang The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Xin Su The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Jie Zhang The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Yanming Li The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Xiuhong Jin The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Rongmeng Jiang The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Jianping Dong The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Yuanlin Song The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Hong Zhou The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Chen Wang The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submission.

Conflict of interest: Bin Cao The co-author and myself do not have any conflict of interest, and all authors have approved the manuscript for submis

sumber : https://erj.ersjournals.com/content/early/2019/05/08/13993003.02406-2018

 
 

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