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Nontuberculous mycobacterial pulmonary disease and Aspergillus co-infection: Bonnie and Clide?


Kim Geurts, Sanne M.H. Zweijpfenning, Lian J. Pennings, Jodie A. Schildkraut, Martin J. Boeree, Cecile Magis-Escurra, Henrich van der Lee, Paul E. Verweij, Wouter Hoefsloot, Jakko van Ingen

European Respiratory Journal 2019; DOI: 10.1183/13993003.00117-2019

Extract

Nontuberculous mycobacteria (NTM) cause difficult-to-treat opportunistic infections, most frequently of the lungs. Patients with COPD, cystic fibrosis or bronchiectasis are prone to non-tuberculous mycobacterial pulmonary disease (NTM-PD) and other opportunistic infections, including by Aspergillus fumigatus. Co-infections are difficult to identify as diagnostic criteria for NTM-PD and chronic pulmonary aspergillosis (CPA) overlap [1, 2]. Literature suggests that NTM and Aspergillusco-infections are associated with higher mortality [3]. Therefore, Aspergillus serology is part of NTM-PD diagnostic work up in our reference center.

Footnotes

This manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.

Conflict of interest: Dr. Geurts has nothing to disclose.

Conflict of interest: Dr. Zweijpfenning has nothing to disclose.

Conflict of interest: Dr. Pennings has nothing to disclose.

Conflict of interest: Dr. Schildkraut has nothing to disclose.

Conflict of interest: Dr. Boeree has nothing to disclose.

Conflict of interest: Dr. Magis-Escurra has nothing to disclose.

Conflict of interest: Dr. van der Lee has nothing to disclose.

Conflict of interest: Dr. Verweij has nothing to disclose.

Conflict of interest: Dr. Hoefsloot has nothing to disclose.

Conflict of interest: Dr. van Ingen reports grants from Netherlands Organization for Scientific Research (NWO/ZonMW grant Veni 016.176.024), during the conduct of the study.

sumber : https://erj.ersjournals.com/content/early/2019/03/15/13993003.00117-2019

 
 

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