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Berita Kesehatan

Respiratory Work and its Components During Exercise in Interstitial Lung Disease, COPD and Controls


Abstract

Introduction: To understand the respiratory work and its components during exercise has important role in exercise limitation in respiratory diseases.

Objective: To evaluate the respiratory work and its components during maximal exercise in interstitial lung disease (ILD) and COPD, compared to controls, using Campbell Diagram.

Methods: 7 ILD patients (47.7�15.4y, FVC 66.1�16.6%pred), 9 COPDs (60.1�8.6y, FEV1 44.2�19.7%pred) and 8 healthy subjects (HS) (53.0�11.2y, FEV1 87.8�13.9%pred) underwent maximal cardiopulmonary cycle ttest and were monitored with esophageal balloon (Pes).

Results: At rest, all groups had similar Pes and tidal volume (Vt). ILD patients had greater Elastic Work, while COPD had the highest Resistive and Expiratory Muscle Work. At intense exercise: (1) HS increased the total Work roughly 3 times, but the Res increased 4 times and the ExpMuscle 11 times; (2) ILD had the worse pressure-volume generation (Pes/Vt); (3) COPD had the lowest increase in ExpMuscle.

Work Of Breathing (J/L) and Pes/Vt at Rest (left) and Final (right) in cycle test

Healthy Subjects (HS) ILD COPD
W Total Ins 0.30�0.15 1.05�0.33 0.41�0.21 1.16�0.24 0.45�0.12 1.37�0.50
W Elastic 0.19�0.07 0.68�0.21 0.31�0.13∗ 0.92�0.33 0.19�0.09 0.73�0.29
W Resistive 0.09�0.08 0.34�0.15 0.08�0.08 0.21�0.16 0.24�0.06∗ 0.71�0.239
W Exp Muscles 0.007�0.008 0.12�0.10 0.008�0.012 0.12�0.11 0.097�0.058∗ 0.10�0.09
Pes/Vt 7.9�3.3 8.1�3.3 14.2�6.9 23.7�21.4� 11.8�7.1 17.2�7.3
  • ∗ p<0.05 vs HS; � p=0.06 vs HS

Conclusions: In healthy subjects, the highest increase of work during exercise comes from the expiratory muscles. ILD has the worse inefficiency to generate volume. Severe COPD has already high ExpMuscle even at rest and they could not increase it substantially at intense exercise.

sumber : https://erj.ersjournals.com/content/46/suppl_59/PA2251

 
 

PRAKTEK Alamat 1:
RS Panti Waluya /RKZ Sawahan, Lt II-N
, Dr Koentjahja, SpP
Nusakambangan 56, Malang 65117
08113777488 / 362017 ext. 88.23
Pukul 17.30 - selesai, kec. Sabtu / Libur

Alamat 2:
RS Lavalette
, Dr Koentjahja, SpP
WR Supratman 10, Malang 65111
08133175788
Selasa & Kamis, Pukul 16.45 - 17.30

    
RUMAHWilis Indah A-6, Malang 65115
0341-568711


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