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Transbronchial Lung Cryobiopsy: Associated Complications


Introduction: Transbronchial lung cryobiopsy (TBC) has emerged as an alternative to surgical lung biopsy in interstitial lung disease (ILD). Besides its less invasive nature, some associated complications have been described.

Objective: To evaluate complications of TBC and associated factors.

Methods: Prospective evaluation of all patients with ILD submitted to TBC in our Center.

Results: Ninety patients were included (mean age 60±13 years; 58,9% male). Twenty-two patients presented pneumothorax [18 (81.8%) patients treated with chest tube drainage; median air leak time=1 day (IQR=2)]. Factors related to pneumothorax were as follow:

Pneumothorax=yes (n=22; 22.4%) Pneumothorax=no (n=68; 75.6%) p
Female gender [n (%)] 13 (35.1) 24 (64.9) 0.049
BMI Kg/m2 [median (IQR)] 30.00 (5.42) 28.85 (7.66) 0.416
Presence of pleura in the histologic sample (vs. pleura absence in the histologic sample) [n (%)] 5 (31.3) 11 (68.7) 0.527
Biopsy >1 lobe (vs. 1 lobe biopsy) [n (%)] 3 (27.3) 8 (72.7) 1
Presence of pleura in the histologic sample (vs. pleura absence in the histologic sample) [n (%)] 1 (5.6) 17 (94.4) <0.0001
UIP/possible UIP histology (vs. other histology types) [n (%)] 1 (5.6) 17 (94.4) 0.062
Fibrotic histology (vs. non-fibrotic histology) [n (%)] 3 (13.6) 19 (86.4) 0.175

Moderate bleeding occurred in 5 patients (5.5%) and 1 patient (1.1%) presented bronchospasm and transient respiratory failure.

Conclusion: The most frequent associated complication to TBC was pneumothorax, although quickly solved. Whereas there were no statistically significant associations between pneumothorax and TBC besides presence of pleura in the histologic sample and female gender, potential candidates to TBC should be carefully selected.

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PRAKTEK Alamat baru:
RS Panti Waluya /RKZ Sawahan, Lt II-N
, Dr Koentjahja, SpP
Nusakambangan 56, Malang 65117
08113777488 / 362017 ext. 88.23
Pukul 18.00 - selesai, kec. Sabtu / Libur
RUMAHWilis Indah A-6, Malang 65115
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