Video
Jajak Pendapat

Penyakit MERS telah masuk di Indonesia melalui jamaah haji maupun umroh, darimana MERS-CoV ditularkan?...

Unta
Kucing
Kelelawar
Monyet
Belum diketahui

Berita Kesehatan
Prevalence of refractory asthma in population with severe asthma

penyakit paru
image: youtube.com


Evgeny Kulikov1, Ludmila Ogorodova2, Ivan Deev2, Natalya Kirillova1 and Sergey Fedosenko1
1Division of General Medical Practice, Siberian State Medical University, Tomsk, Russian Federation, 2Division of Faculty Pediatrics, Siberian State Medical University, Tomsk, Russian Federation



Background:
Severe persistent asthma is associated with high morbidity, among patients with severe asthma, higher risks can be expected in patients with refractory asthma, but little is known about clinical factors which associated with refractory (therapy-resistant) asthma.

Aims and objectives: To compare prevalence and clinical characteristics of refractory asthma in severe asthma population.

Methods: Prospective, interventional, controlled study in parallel groups with 6 month treatment period was performed. Patients with severe uncontrolled disease and appropriate (GINA) treatment administered were included in the study. According to treatment response patients were aposterior divided according to ATS 200 criteria into groups of severe or refractory asthma.

Results and conclusion: Initially, in the group of refractory asthma worse clinical and functional parameters of asthma course were registered compared with severe asthma. According to our data the prevalence of refractory asthma in population with severe asthma is more than 50%.



Parameter Severe asthma (n=19) Refractory asthma (n=21)
Age, years 47,15±3,20 51,40±2,52
Day symptoms per week 12,45±1,51 21,35±2,13*
Night symptoms per week 2,55±0,47 5,05±1,15
Disease duration, years 9,75±1,94 16,65±1,88*
Age of disease manifestation 33,30±3,91 28,15±3,78
Frequency of emergency calls per year 0,15±0,15 2,60±1,23*
Number of visits to the doctor per year 3,40±1,10 2,95±0,96
FEV1, % 68,10±1,89 61,97±1,97*
PEF, % 73,84±3,56 68,51±2,82
FVC 87,61±2,82 85,10±2,95
Reversibility, %FEV1 24,94±1,96 31,27±2,99
ACT score 15,30±0,58 12,40±0,89*
  • *-p<0.05

  • Clinical characteristics of refractory asthma in comparison with severe asthma



    Source : http://erj.ersjournals.com/content/48/suppl_60/PA4180
    Image : https://i.ytimg.com/vi/YP0sO0tPo5A/...
     
     

    PRAKTEK Alamat lama:
    Apotik Kimia Farma 53
    Kawi 22A, Malang
    Alamat baru: (TMT 1/1-13)
    RS Panti Waluya Sawahan / RKZ,
    Lantai II-N

    Nusakambangan 56, Malang 65117
    08113777488 / 362017 ext. 88.23
    Pukul 18.00 - selesai, kec. Sabtu / Libur
    RUMAHWilis Indah A-6, Malang 0341-568711

    Peta Lokasi